STUDIES TO VERIFY APPLICATION BENEFITS OF SPECIFIC NEEDS

Studies, on application benefits of specific needs, would be directly relevant to preventative health care of the inactive population in general and target directly to patients and cover the following resulting from short centrifugation/artificial G exposures as follows:
 
1.  Persons with metabolic disorders like obesity and diabetes.
 
2.  Athletes and others confined to bed rest due to their injuries. 

 

3.  Stimulation of glutathione, growth hormones & other inflammatory markers, especially counteracting the effects of insulin resistance, healing & inflammation together with lipid mobilization to benefit obesity and diabetes.
 
4.  Increase in muscle synthesis with increased muscle mass and strength, even without exercise during centrifugation,  These effects would have great value in maintaining muscle mass in the elderly population or rehabilitation at any age.

 

5.  Secondary to muscle metabolic changes would be expected, though not documented, parallel changes in bone density and strength mobilization of fat from bone marrow and other sources, wound healing and positive immune system activity.

Three additional articles by Joan Vernikos PhD

Gravity and Hypergravity (paper for Hippokratia GASMA supplement 2010 meeting)

GERONTOLOGY 102309Pub 

Gravity Theropy

Note:  Dose response studies have not been done to determine level of centrifugation to effect. In animals chronic centrifugation at low levels reduces insulin levels, suggesting beneficial change in down- regulating insulin resistance.
 
6.  Centrifugation particularly intermittent could mimic changes in posture. This would induce an increase and decrease in cardiovascular shifts as well as oxygenation and increased brain blood flow.  
 
7.  Modern monitoring technologies could be recommended to users so that they could have feedback on heart rate, blood pressure, blood oxygen and even temperature.  
 
8.  Recommendations could be made to centrifuge users to monitor their daily activity eg. In total daily steps.  The total number of steps per day is known to increase under conditions of some type of once a day intervention.  Also such circulation changes or even independent of circulation could benefit cognition.
 
9.  Essentially the influence of centrifugation is like isometric or resistive activity. 


10.  The neurological benefits are unlimited in the area of brain injuries and neuro degeneration from dementia and alzheimer’s. 

bone-physiology.png

Metabolism is changed, with fat accumulating to replace lost muscle and fatty oxidation with a reduced capacity to use fats for energy. In addition to metabolic changes, intermittent exposure to centrifugation mimicking alternating standing and sitting, draws fluids to the feet resulting in secondary increased heart rate, blood pressure, stroke volume, baroreflex sensitivity, increased blood volume and an altogether better functioning cardiovascular system. Centrifugation, as with an intense exercise bout, would probably lead to an endothelial ‘nitric oxide dump’ that would benefit blood vessel responsiveness. Both in space and ageing, endothelial lining atrophies with resulting vascular weakness. Centrifugation has also been found to improve parasympathetic nervous system function as well as brain blood flow and oxygen saturation, all desirable features of improved health and brain function.

Gravity Deprivation

On Earth the effect of gravity is fairly straightforward. It pulls in one direction only, downward, towards the center of the Earth. Unlike plants, humans have the choice of orienting themselves relative to the force of gravity in every conceivable way and mostly in intermittent patterns. They also reduce gravity’s effects on the body during sleep at night or in continuous bed-rest when they are lying in bed. They can also enhance its force with various activities such as walking, running, jumping, bouncing on a trampoline or riding on a centrifuge. How we sense and use gravity determines our health and fitness. The most evident is that of loading, which imparts weight to the body when gravity is pulling in the head to foot direction (+Gz). We are aware of exertion against the force of gravity during normal activity of moving and walking. 

space.png

Gravity is obviously involved in postural and other changes in movement and direction, such as giving cues about our spatial orientation relative to gravity’s vertical pull. Without regular exposure to these +Gz forces, as occurs during spaceflight and prolonged bed-rest, significant cardiovascular, musculoskeletal, metabolic, neural and primarily neuro-vestibular mediated functions are compromised.'

Gravity Therapy


A gravity stimulus may be provided in the form of a rotating short-arm centrifuge. Accepting that ageing is primarily a Gz-deprived condition, then it follows that gravity therapy would be a logical treatment during ageing or as a preventive measure in other degenerative conditions or injuries.
If these are caused or worsened by gravity-deprivation then it stands to reason that gravity replacement or treatment should provide relief. These include:

  • Increasing the frequency of your G-Using Habits such as climbing stairs

  • Playing

  • Incorporating G-Using Exercise such as skipping rope or jumping

  • Vibration

  • Hypergravity  – Using a Centrifuge to increase the G-load on the body.

short-arm-centrifuge.png

Vibration stimulates the circulation. Centrifugation on Earth has been found to be anabolic. It stimulates muscle protein synthesis, mass, strength as well as bone strength indirectly and directly through periods of intermittent whole-body loading.

 

However, relatively little is known about how much and when such artificial gravity is optimal in humans. Studies in animals - rats, mice, rabbits, chickens –were exposed to 2G, 24h/day for 20 days with a short daily stop for cleaning and feeding. Such chronic exposure to 2G resulted in reduced food intake, loss in body fat, increased muscle and bone mass and strength, reduced insulin levels and insulin resistance. On the other hand, human studies have followed the exercise once-a-day custom, and used centrifugation only once a day at levels varying from 0.5 to 1G, however, these once-a-day protocols have proven to be only partially beneficial.


A twice or three times a day G-exposure would come closer to the ideal G stimulation we are exposed to as we move around and change posture throughout the day. In research that I and my colleagues conducted (published 1996) involving volunteers deconditioned by lying in bed continuously, we tested the effect of the 1Gz stimulus of standing up for 15 minutes every two hours throughout the 16-hour day. This schedule was completely effective in maintaining aerobic conditioning, blood volume, cardiovascular responsiveness, and preventing calcium loss from bone, whereas standing up for this time period every 4 hours was found to be less effective.


Clinical applications of Gravity therapy could include, but are not limited to :-osteoporosis, accelerated repair of bone fracture from sports injuries, in the elderly or paraplegics, less insulin resistance in diabetics, increased muscle mass in conditions of muscle wasting, joint deterioration aggravated by weight bearing and potentially certain forms of pulmonary edema or concussion.


What is undoubtedly true is that for many of us our modern lifestyle does not provide the level of activity of our parents and grandparents. We have struggled for decades to exercise more and eat less, but one thing hasn’t changed: we still spend hour after hour each day virtually immobile in our chairs. Our lives have become sedentary and the way we live affects, not only our physical health, but our emotional and mental wellbeing. From the more complex perspective of exercise equipment or centrifuges, to the more everyday and accessible activities that everyone can incorporate into their daily lives, such as simply standing up every 15 minutes or taking the stairs instead of the elevator, using gravity in our favour and as a therapy will become more and more important as we age, helping to maintain the balance and strength we need to continue performing basic life functions. 
________________________________________
“There is much that is not known about how gravity is sensed and translated into input to every system in the body. This includes its required threshold, frequency, intensity, duration and direction. Space provides the ideal environment to tease out these aspects of gravity. This is crucial so that we may understand the requirements for replacing gravity in the countermeasure formula for exploration missions as well as expanding our knowledge in basic human physiology on Earth.” 
Joan Vernikos, Hippokratia, 2012.

NEWS & VIEWS

Gravity Therapy

Blog written by Dr. Joan Vernikos, InnovaSpace Advisory Board Member, former Director of Life Sciences NASA, 
Founder of Thirdage llc, Culpeper VA, USA
The influence of gravity in human health on Earth has been grossly underestimated. Only through the experience of human spaceflight some 60 years ago did it become apparent that changes induced by living in the microgravity of space were not simply due to inactivity, as was originally thought. Unlike other variables like heat, cold or altitude, there is no evidence that the human body adapts to living with less or no gravity.

In fact, the longer humans are in space the faster the degenerative changes seem to occur, despite significant exercise and attempts at other countermeasures. With durations lasting six or more months and better diagnostic techniques, it can be seen that living in space accelerates tenfold the rate of decrease in bone density, when measured over the same time in the average population on Earth.

FUNCTIONAL NEUROLOGY

Brain injuries are a growing concern in all areas especially in the sports of football, soccer, hockey, etc.  These brain injury concerns start at the grade school level and continue into professional sports.  These brain injuries are accumulative and in many cases lead to early death as proven by numerous football statistics.  The future of football and other brain injury sports, that start early in life, could be determined by mothers of children in these activities.

The centrifuge exerciser can also be utilized in multimodal customized brain injury rehabilitation protocols.  Our brain contains billions of neurons connected in a manner that allows for incredible function. 

During a concussion, these axonal connections are stretched causing inflammation and injury to our brain.  These axons will eventually heal often leaving a person tormented with symptoms associated with post-concussion syndrome. 

Vertigo, dizziness, visual disorders, bowel and bladder problems, sexual dysfunction, numbness, and tingling, reduced ability to focus or concentrate, fatigue, anxiety, depression, decreased muscle strength and flexibility, increased joint stiffness, and reduced stamina are just some of the symptoms associated with traumatic brain injuries. 

After a comprehensive examination, the areas of neurological deficits are found, and the working diagnosis is made, a comprehensive treatment plan can be implemented and the patient’s response to this initial care plan is objectified through additional examinations and functional outcome assessments.

 

Even though the amount of central nervous system rehabilitation can be limited, use of the CENTRIFUGE exerciser enhances neuroplasticity or compensation by stimulating the brain to use other senses to substitute for injured axonal connections giving suffering people a chance to feel and function better.

See link to: 

"New Science of Concussions", regarding  CTE - "Chronic Traumatic Encephalopathy" and TBI, -  Truamatic Brain Injury".

References:

¹Vernikos J, Schneider VS. (2010) Space Gravity and the Physiology of Aging: Parallel or Convergent Disciplines? A Mini Review, Gerontology56(2)121-240.
²Mulvaugh SL, Charles JB, Riddle, JM, Rehbein,TI, Bungo,MW.(1991) Echocardiographic evaluation of the cardiovascular effects of short-duration spaceflight. J Clin Pharmacol 31:1024-1026.
³ Levine BD, Lane ID, Watenpaugh DE, Gaffney FA, Buckey JC, Blomquist CG. (1996) Maximal exercise performance after adaptation to microgravity J Appl Physiol.81:686-694.
⁴ Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I. (2002). Human muscle sympathetic neural and hemodynamic responses to tilt following spaceflight. J Physiol 538:331-334.
⁵ Vernikos J, Ludwig DA, Ertl AC, Wade CE, Keil LC, O’Hara D.  (1996).  Effect of standing or walking on physiological changes induced by head down bed rest.  Aviat. Space Environ. Med. 67:1069-1079.
⁶ Convertino VA. (2002). Mechanisms of microgravity-induced orthostatic intolerance: implications for effective countermeasures. J.Gravit Physiol 9:1-13.
⁷ Delp MD (2007). Arterial adaptations in microgravity contribute to orthostatic tolerance. J Appl Physiol. 102:836.
⁸ Evans, JM, Knapp CM, Goswami. N, (2018). Artificial Gravity as a Countermeasure to the Cardiovascular Deconditioning of Spaceflight: Gender Perspectives,Frontiers in Physiology, July, 2018, doi:10.3389/phys.2018.00716
⁹Sasaki T, Iwasaki K I, Hirayanagi K, Yamaguchi N, Miyamoto A and Yajima K. (1999). Effects of daily 2Gz load on human cardiovascular function during weightlessness simulation using 4-day head-down bed rest. Jpn. J. Aerospace Environ. Med. 36:113–123. 
¹⁰Ritweger J, Bareille M-P, Clement G, Linnarson D, Paloski WH, Wuyts F, Zange J, Angerer O. (2013) Short-arm centrifugation as a partially effective musculoskeletal countermeasure during 5-day head-down tilt bed rest – results from the BRAG1 study. Eur.J.Appl Physiol. 113:1233-1244.DOI: 10:1007:/s00421-015-310-
¹¹ Diaz-Artiles A, Heldt T, Young LR. (2018) Short-term Cardiovascular Response to Short-Radius Centrifugation with and without Ergometer Exercise. Front Physiol.Nov13;9:1492. Doi: 10.3389/fphys.2018.01492.2018.
¹² Li XT, Yang CB, Zhu YS, Sun J, Shi F, Wang YC, Gao Y, Zhao JD, Sun XQ. (2017) Moderate exercise based on artificial gravity preserves orthostatic tolerance and exercise capacity during short-term head-down bed rest. Physiol Res. 2017 Sep 22;66(4):567-580. 
¹³ Kaderka JD (2010) A Critical Benefit Analysis of Artificial Gravity as a
Microgravity Countermeasure. MIT PhD thesis, pp.1-187

¹⁴Goswami, N. (2017). Falls and fall-prevention in older persons: geriatrics meets spaceflight! Front. Physiol. 8:603. doi:10.3389/fphys.2017.00603.
¹⁵ Martinez DA, Patterson-Buckendahl PE, Lust A, Shea-Rangel KM, Hoban-Higgins TM, Fuller CA, Vailas AC (1985). A noninvasive analysis of urinary musculoskeletal collagen metabolism markers from rhesus monkeys subject to chronic hypergravity. J.Appl Physiol.(1985)) 2008Oct, 105(4):1255-1261.
¹⁶ Evans JW, Smith AH, Boda JM. (1969) Fat metabolism and chronic acceleration. AmerPhysiol–Legacy Content 216:148-147.

¹⁷Evans J. W, Boda JM. (1970). Glucose metabolism and chronic acceleration. AmerJPhysiol–Legacy Content 219: 893-896.
¹⁸ McGeoch PD, McKeown J, Ramachandran Vilayanur S. Jones T, Jones SM, =Fuller SM (2016). Modulation of Body Mass Composition using Vestibular Nerve Stimulation, BioRx iv:087692.
¹⁹ Fuller, PM, Jones, T, Jones, SM, Fuller CA. (2002) Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection? Proc Nat Acad Sci 99(24):15723-15728.
²⁰ Strollo F, Banger L, Fuller C. (2000) Testosterone urinary excretion rate increases during hypergravity in male monkeys. J Grav Physiol Jul 7 (2):181-182.

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